Veterans Health Library
idelalisib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. imatinibimatinib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
StatPearls [Internet].
Increases the risk of severe hypotension and syncope. fluconazolefluconazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fluconazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fosamprenavirfosamprenavir will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fosamprenavir will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Pediatric Precautions
fosaprepitantfosaprepitant will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fosaprepitant will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. grapefruitgrapefruit will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. grapefruit will increase the libido for women level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. idelalisibidelalisib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. imatinib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. isoniazidisoniazid will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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isoniazid will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. itraconazoleitraconazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
What is Addyi (flibanserin)?
darunavirdarunavir will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. darunavir will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. diltiazemdiltiazem will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. diltiazem will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dronedaronedronedarone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
What should I tell my healthcare provider before using Addyi?
dronedarone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. erythromycin baseerythromycin base will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. erythromycin base will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. erythromycin ethylsuccinate will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. erythromycin lactobionateerythromycin lactobionate will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Addyi affects
erythromycin lactobionate will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. erythromycin stearateerythromycin stearate will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. erythromycin stearate will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. Coadministration of flibanserin within 2 hr of consuming alcohol is contraindicated. itraconazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
- Flibanserin is used to treat premenopausal women with hypoactive sexual desire disorder (HSDD).
- It is marketed under the brand name Addyi.
- Flibanserin works by modulating serotonin and dopamine levels in the brain.
- It was approved by the FDA in 2015 for HSDD treatment.
- Common side effects include dizziness, nausea, and fatigue.
- Flibanserin is usually taken once daily at bedtime.
- It has contraindications with alcohol due to risk of severe hypotension.
- Patients should avoid alcohol while using flibanserin.
- It is a non-hormonal medication specifically for sexual desire issues.
ketoconazoleketoconazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ketoconazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Interaction Partner | Effect | Advice |
|---|---|---|
| Alcohol | Increased sedation and hypotension | Avoid concurrent use |
| CYP3A4 inhibitors | Elevated flibanserin levels | Dose adjustment or avoid |
| Other serotonergic agents | Increased risk of serotonin syndrome | Avoid concomitant use |
lapatiniblapatinib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lapatinib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lenacapavirlenacapavir will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
WHY is this medicine prescribed?
bicalutamide will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinibceritinib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme fildena 200 mg CYP3A4 metabolism. ceritinib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ciprofloxacinciprofloxacin will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ciprofloxacin will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
What should I do if I miss a dose of Addyi?
clarithromycinclarithromycin will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clarithromycin will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cobicistatcobicistat will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cobicistat will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. conivaptanconivaptan will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Hepatic Impairment
conivaptan will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. crizotinibcrizotinib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. crizotinib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cyclosporinecyclosporine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cyclosporine will increase the level or effect of bayer vardenafil flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lenacapavir will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Region | Estimated Cost per Month | Generic Version Available |
|---|---|---|
| USA | $400 | No |
| EU | €350 | No |
| Australia | AUD 550 | No |
| India | Approx. $50 (generic) | Yes |
levoketoconazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Issue | Description |
|---|---|
| Efficacy Debate | Some experts question the clinical significance of benefits |
| Side Effect Concerns | Risks of hypotension, syncope, and severe allergic reactions |
| Marketing & Approval Controversies | Criticism over FDA approval process and marketing practices |
| Post-Marketing Surveillance | Ongoing monitoring for rare adverse events |
lidocainelidocaine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
- Global availability varies; approved in the US, Canada, and some other countries.
- Not approved in the European Union by the EMA as of current knowledge.
- Different brand names may be used in countries where it is marketed.
- Importing for personal use from other countries carries risks and is often illegal.
- Counterfeit versions of the medication are a potential danger.
- Patients should only obtain it from a certified, licensed pharmacy.
- Telemedicine may be used for consultations but REMS requirements still apply.
- The future of flibanserin may involve generic competition reducing cost.
- Research into its potential effects on other conditions (e.g., depression) is limited.
lidocaine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
What special precautions should I follow?
Flibanserin has high affinity for human 5-HT1A receptors (Ki = 1 nm) and lower affinity for 5-HT2A (Ki = 49 nm) and D4 (Ki = 4–24 nm) receptors, and negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin was investigated as a novel, non-hormonal treatment for pre-menopausal women with Hypoactive Sexual Desire Disorder (HSDD). Recently, Flibanserin was found to reduce L-DOPA-induced dyskinesia in a model of Parkinson′s Disease. This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products.
Sample Use Guides
Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects Choose from one of the most recent versions: Find documentation for the products that you have recently purchased in the Document Library. Indicated for women aged <65 years with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT caused by: a coexisting medical or psychiatric condition; problems within relationship; or effects of a medication or other drug substance 100 mg PO once daily at bedtime Dosed at bedtime because administration during waking hours increases risks of hypotension, syncope, accidental injury, and CNS depression Discontinued after 8 weeks if no improvement Coadministration with moderate or strong CYP3A4 inhibitors is contraindicated If initiating flibanserin following moderate or strong CYP3A4 inhibitor use, start flibanserin 2 weeks after last CYP3A4 inhibitor dose If initiating a moderate or strong CYP3A4 inhibitor following flibanserin use, start moderate or strong CYP3A4 inhibitor 2 days after last flibanserin dose Acquired HSDD refers to HSDD that develops in a patient who previously had no problems with sexual desire Generalized HSDD refers to HSDD that occurs regardless of type of stimulation, situation, or partner Not indicated for HSDD in postmenopausal women or in men amiodaroneamiodarone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of flibanserin with moderate or strong CYP3A4 inhibitors is contraindicated. amiodarone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Storage Requirements
aprepitantaprepitant will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. aprepitant will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. atazanaviratazanavir will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. atazanavir will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. bicalutamidebicalutamide will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lopinavirlopinavir will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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