Comparing Common ED Medications: Efficacy and Duration

These patterns can be seen in the table below (AEs for which there were 1 or 2 study arms are omitted); see cells in bold.

Drug	Effectiveness (%)	Onset Time	Duration of Action	Patient Satisfaction Rate
Viagra	70-80	30-60 min	4-6 hours	75%
Cialis	75-85	30 min	Up to 36 hours	80%
Levitra	65-75	25-60 min	4-5 hours	70%
Stendra	70-80	15-30 min	Up to 6 hours	78%

Appendix B2 – Guideline Statement 16: Intracavernosal injection (ICI) data Commonly reported adverse events in fildena

Is one drug better than another?

In the future, diverse ED treatments likely will become available and can be offered in a highly effective, clinicopathologically targeted manner as linked with cause-specific ED-associated disease states. It is conceivable that the ED treatment armamentarium of the future will comprise therapies specific for diabetes-associated ED, for instance, that are distinct from those intended for neurogenic ED or severe vasculogenic ED. Improved diagnostics will have impact in this scope as well. Molecular profiling, genetic biomarkers and advanced imaging techniques may improve the specificity of treatment for each man and usher in an era of "personalized medicine" for ED. Current interventions for ED are focused on symptomatic benefit.

Can you use baking soda for erectile dysfunction treatment?

For example, although oral PDE5i were a major therapeutic breakthrough and now constitute a mainstay of ED management, these medications only mitigate symptoms rather than curing the underlying condition. Therapies with less restrictive, non-repetitive efficacy are greatly needed. The ultimate goal of ED management is to restore physiologically intact and natural erectile function. Durable and clinically significant improvement in erectile function is a less optimal but still desirable goal if total recovery is not an option. Improvements in our ability to definitively manage ED will likely contribute to better life satisfaction and superior overall health outcomes. 200 mg extracted ICI studies: Appendix B3– Guideline Statement 18: Penile prosthesis data Patient and partner satisfaction data:

Treatment Option	Description	Effectiveness	Benefits	Limitations
Vacuum Erection Devices	External pump creates vacuum to induce erection	Moderate	No drugs required, reversible	Discomfort, mechanical failure
Penile Implants	Surgical insertion of device	High	Permanent solution	Surgery risks, costs
Psychosexual Therapy	Counseling for psychological issues	Varies	Addresses underlying causes	Time-consuming, requires cooperation
Lifestyle Changes	Exercise, diet, quitting smoking	Moderate	Improves overall health	Requires consistency

Appendix B4 – Guideline Statement 21: Penile arterial reconstruction data Complete, partial, and non-response rates to surgery: Below are those data; for studies that reported response rates at different durations post-surgery, the latest duration was used.

Product	Dosage	Quantity + Bonus	Price
Cialis Generic	60mg	30 + 2 Pills	85.33€ 81.27€	Buy
Cialis Generic	5mg	180 + 10 Pills	159.65€ 152.05€	Buy
Viagra Generic	50mg	120 + 6 Pills	129.64€ 123.47€	Buy
Levitra Generic	40mg	10 Pills	41.37€ 39.40€	Buy
Viagra Generic	25mg	90 + 6 Pills	105.03€ 100.03€	Buy
Tadalista Super Active	20mg	180 + 20 Pills	521.59€ 496.75€	Buy
Cialis Generic	2.5mg	60 + 4 Pills	83.43€ 79.46€	Buy
Cialis Black	80mg	270 + 10 Pills	502.88€ 478.93€	Buy
Levitra Professional	20mg	180 + 4 Pills	502.31€ 478.39€	Buy
Viagra Generic	25mg	180 + 6 Pills	154.93€ 147.55€	Buy
Cialis Generic	60mg	60 + 4 Pills	145.06€ 138.15€	Buy
Viagra Professional	100mg	20 Pills	71.14€ 67.75€	Buy
Cialis Original	20mg	76 + 4 Pills	319.19€ 303.99€	Buy
Levitra Soft Tabs	20mg	120 + 8 Pills	288.52€ 274.78€	Buy
Kamagra	100mg	84 + 6 Pills	264.44€ 251.85€	Buy
Kamagra Soft Tabs	100mg	180 + 8 Pills	425.45€ 405.19€	Buy

Appendix B5 – Guideline Statement 22: Penile venous surgery data Complete, partial, and non-response rates to surgery: The pattern of declining positive response rates over time can be seen in the scatterplot below which plots complete and partial responder rates by follow-up duration. The exception to this trend is Hsu, Chen (2010) who reported that 85.6% of 167 Taiwanese men at 92.4 mos of follow-up were complete responders to venous ligation surgery[926].

Viagra (sildenafil)

When means for the general and four special populations (men with diabetes, with BPH/LUTS, post-RP, or post-RT) for which there are substantial data were examined, it appears that men post-RP and men post-RT reported substantially higher rates of AEs than did men in the general ED population. Whether men who have had prostate cancer treatment are more likely to experience AEs or are more likely to report AEs is not clear. Men post-RP reported higher rates of AEs in response to sildenafil than in response to other PDE5s. Men post-RT reported high rates of AEs across PDE5s and in placebo groups. The high rates of AEs reported by men in placebo groups suggest that men post-RT may have heightened sensitivity to body sensations and may have unmet needs for psychosocial support. These men had no comorbidities at the time of surgery.

Medication	Common Side Effects	Serious Risks	Contraindications
Sildenafil	Headache, flushing	Vision changes, priapism	Nitrate therapy, heart conditions
Tadalafil	Muscle pain, flushing	Sudden vision loss	Same as above
Vardenafil	Dizziness, nasal congestion	Priapism	Use with caution in cardiovascular disease
Avanafil	Flushing, back pain	Hypotension	Avoid with certain medications

The procedure involved stripping and ligation of the deep dorsal, emissary, and cavernosal veins as well as ligation of the para-arterial veins; some men also had ligation of the crural veins.

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PDE5i have similar efficacy in the general ED population. Examination of data reported by trials that evaluated fildena super active 100 PDE5i revealed that these medications had similar efficacy among men in the general ED population, defined as men with a variety of underlying conditions that potentially contributed to ED symptoms. This pattern was evident when raw data were examined [see International Index of Erectile Function-Erectile Function (IIEF-EF) subscale table in guideline] as well as when the subset of data that could be meta-analyzed were pooled. The same patterns can be seen in the graph below that plots mean IIEF-EF baseline scores and mean post-treatment scores for each study by medication (symbols above the diagonal line reflect increased scores from baseline to post-treatment. Active treatment groups generally cluster above the placebo groups without clear separation among medications.1 Similar patterns are evident for other measures.

Heart Disease/High Blood Pressure

Data from the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) are below; mean satisfaction scores (possible range 0 to 100) are similar across active medications (limited data available for tadalafil and vardenafil). The same pattern is evident for the Sexual Encounter Profile (SEP) question 2 ("Were you able to insert your penis into your partner's vagina?") and question 3 ("Did your erection last long enough for you to have successful intercourse?"). The percentages of men who respond "yes" are relatively similar across active medications (limited data are available for avanafil). A subgroup of studies used global assessment questions (GAQ 1 and 2) or global efficacy questions (GEQ 1 and 2). The phrasing of the questions differs, but essentially question 1 asks whether the study vidalista 20mg uk medication has improved erections and question 2 asks whether, if the treatment has improved a man's erections, has his ability to engage in sexual activity improved. Overall, there was considerable variability regarding response rates.

• Hormonal therapy may be necessary if low testosterone is diagnosed.
• Testosterone replacement therapy can improve libido and function.
• Blood tests are needed to confirm hormone levels.
• This therapy may come with side effects like acne or sleep apnea.
• Not suitable for men with certain prostate conditions.
• Always seek professional guidance before hormone treatment.

Below are those data; for studies that reported response rates at different durations post-surgery, the latest duration was used.

Metrics & Citations

Again, there are no clear differences across medications (limited data for avanafil). Dose-response effects across PDE5i medications are small and non-linear (i.e., doubling the dose does not double the effect). Higher doses may produce higher average effects but dose groups generally were not statistically significantly different unless comparing extremely low doses to extremely high doses. The magnitude of average increased effects with increased doses is small and often not clinically significant (e.g., a one or two point increase on the IIEF-EF). IIEF-EF data for trials of sildenafil, tadalafil, and vardenafil that used fixed doses are below (insufficient data for avanafil).

Tools & Resources

On demand dosing vs. daily dosing for tadalafil appears to produce the same level of efficacy. Note that daily dosing trials generally used lower doses than did on demand trials. Trials of sildenafil and avanafil used only on demand dosing. Data from trials that evaluated men from the general ED population are below. This document was written by the Erectile Dysfunction Guideline Panel of the American Urological Association Education and Research, Inc., which was created in 2016.

How do ED drugs work?

Tadalafil was the only medication for which there were substantial on demand vs. daily dosing studies. Most AEs follow a dose-response pattern such that men in active treatment arms reported statistically significantly higher rates of AEs than did men in placebo arms and the percentage of men reporting a particular AE increased as dose increases. Within individual studies, however, the differences between dose groups were usually not statistically significantly different. Data from studies of men in the general ED population that administered medications at fixed doses (i.e., did not allow the patient to titrate dose up or down) are below. The Practice Guidelines Committee (PGC) of the AUA selected the committee chair.

• Sildenafil (Viagra): A popular PDE5 inhibitor to treat erectile dysfunction.
• Tadalafil (Cialis): Offers longer-lasting effects for up to 36 hours.
• Vardenafil (Levitra): Acts quickly and lasts several hours.
• Stendra (Avanafil): Provides rapid onset of action within 15 minutes.
• Alprostadil (injection): Penetrates directly into the penis to induce an erection.
• Erectile dysfunction patches: Topical patches delivering medication for quicker absorption.

Panel members were selected by the chair.

• ED is often a sign of underlying health problems.
• Cardiovascular health directly affects erectile function.
• Managing chronic illnesses can prevent or improve ED.
• Proactive lifestyle and medical management are essential.
• Emotional well-being is also a key factor.
• Addressing root causes offers the best long-term solution.

Membership of the Panel included specialists in urology, family medicine, and psychology with specific expertise on this disorder.

What are the risk factors for erectile dysfunction?

For men with ED, platelet-rich plasma (PRP) therapy should be considered experimental. Advancements in ED management can be expected to continue into the future in parallel with ongoing progress in the field of sexual medicine more broadly. Developments in health care delivery, diagnostics, and therapeutics will be the underpinnings of improved, evidence-based clinical practice in this field. Although much has been learned in the physiology and molecular science of penile erection in recent decades, scientific discovery in this arena will predictably continue to be made. Science and technology are the cornerstone for new developments ranging from new pharmacotherapeutics to surgical innovations.

Table 1. Risk Factors for Erectile Dysfunction

Scientific discovery in the vascular biology and neurophysiology of penile erection will continue to take center stage with particular focus on molecular and cellular signaling pathways and growth factor mechanisms that may be exploited to produce the next generation of pharmacotherapeutics as well as gene, stem cell and regenerative therapies. Technologic advancements can also be expected to impact surgical procedures ranging from penile reconstructive to prosthetic to tissue replacement surgeries (e.g., penile transplantation). The field is positioned to bring forward single or combination therapies that characterize angiogenic, neurogenic, anti-fibrotic, anti-apoptotic, and other potential systems biologic approaches, which can be directed toward ED pathophysiologic conditions existing at either peripheral (i.e., genitalia) or central (i.e., brain and spinal cord) axis levels. A near-term practical scheme is to apply such treatments based on the systemic deficiency and severity extent of ED, utilizing a SDM process that is guided by the clinician after thorough discussion of all management considerations and incorporates intervention preferences of the man and his partner. Accordingly, a lesser presentation of vasculogenic ED may do well with as needed oral pharmacotherapy and lifestyle improvement whereas a more severe, tissue fibrotic presentation may require tissue regenerative and/or surgical interventions. The mission of the Panel was to develop recommendations that are analysis-based or consensus-based, depending on Panel processes and available data, for optimal clinical practices in the treatment of muscle-invasive bladder cancer.

• Medications for ED should be used strictly as prescribed.
• Overuse or misuse of drugs can lead to complications.
• Not all men will respond to the same medication.
• Combining treatments might provide better results.
• Keep medication away from children and pets.
• Always inform your doctor about other health conditions.

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