The Chemical Structure of Sildenafil Citrate

The makers of these brands are not affiliated with and do not endorse Pfizer Inc or its products.

Contraindication	Explanation	Severity Level	Notes
Nitrates use	Can cause severe hypotension	Critical	Avoid concomitant use
Heart conditions	Risk of cardiovascular events	Moderate	Consult healthcare provider
Hypotension	Low blood pressure	Moderate	Use with caution
Retinal Disorders	Potential for vision impairment	Mild	Seek medical advice

Phosphodiesterase Inhibitors for EDPhosphodiesterase Inhibitors for PAH May be administered without regard to meals.

Non-medical use

Do not take SILDENAFIL CITRATE TABLETS if you take medicines called guanylate cyclase stimulators which include: Riociguat (Adempas®) a medicine that treats pulmonary arterial hypertension and chronic-thromboembolic pulmonary hypertension. Tell all your healthcare providers that you take SILDENAFIL CITRATE TABLETS. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took SILDENAFIL CITRATE TABLETS. Ask your doctor if your heart is healthy enough to handle the extra strain of having sex. SILDENAFIL CITRATE TABLETS does not protect you or your partner from getting sexually transmitted diseases, including HIV—the virus that causes AIDS.

Less common

SILDENAFIL CITRATE TABLETS is a prescription medicine used to treat erectile dysfunction (ED). You will not get an erection just by taking this medicine. SILDENAFIL CITRATE TABLETS helps a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated). SILDENAFIL CITRATE TABLETS is not for use in women or children. It is not known if SILDENAFIL CITRATE TABLETS is safe and effective in women or children under 18 years of age.

What happens with ED?

Who should not take SILDENAFIL CITRATE TABLETS? Do not take SILDENAFIL CITRATE TABLETS if you: take medicines called nitrates (such as nitroglycerin) use street drugs called "poppers" such as amyl nitrate or amyl nitrite, and butyl nitrate take any medicines called guanylate cyclase stimulators such as riociguat (Adempas) are allergic to sildenafil, as contained in SILDENAFIL CITRATE TABLETS and REVATIO, or any of the ingredients in SILDENAFIL CITRATE TABLETS. See the end of this leaflet for a complete list of ingredients in SILDENAFIL CITRATE TABLETS. What should I tell my healthcare provider before taking SILDENAFIL CITRATE TABLETS? Before you take SILDENAFIL CITRATE TABLETS, tell your healthcare provider if you: have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve or heart failure have had heart surgery within the last 6 months have low blood pressure, or high blood pressure that is not controlled have had an erection that lasted for more than 4 hours have problems with your blood cells such as sickle cell anemia, multiple myeloma, or leukemia have retinitis pigmentosa, a rare genetic (runs in families) eye disease have ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) have kidney problems or are having kidney dialysis Tell your healthcare provider about all the medicines you take1, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Shake well for at least 10 seconds prior to each administration.Measure dose with an oral dosing syringe or calibrated measuring device.Concentration of the suspension is 10 mg/mL.

• Sildenafil’s development marked a breakthrough in ED treatment.
• It has revolutionized sexual health for many men globally.
• The drug’s mechanism enhances nitric oxide effects.
• Many patients report improved confidence with sildenafil use.
• Research continues on new formulations and delivery methods.
• Public health campaigns promote safe and effective usage.
• Awareness of contraindications reduces health risks.

Oral suspension (e.g., Liqrev)Storage: Store at room temperature of 20 to 25 degrees C (68 to 77 degrees F).

Product	Dosage	Quantity + Bonus	Price
Viagra Generic	50mg	360 + 10 Pills	225.33€ 214.60€	Buy
Kamagra Polo	100mg	60 + 4 Pills	189.39€ 180.37€	Buy
Viagra Generic	50mg	270 + 8 Pills	198.48€ 189.03€	Buy
Viagra Generic	25mg	180 + 6 Pills	154.93€ 147.55€	Buy
Viagra Generic	150mg	60 + 4 Pills	111.25€ 105.95€	Buy
Kamagra Oral Jelly	100mg	220 + 18 Sachets	662.24€ 630.70€	Buy
Viagra Generic	200mg	60 + 4 Pills	125.19€ 119.23€	Buy
Viagra Generic	100mg	180 + 8 Pills	199.37€ 189.88€	Buy
Viagra Generic	200mg	270 + 10 Pills	379.76€ 361.68€	Buy
Viagra Generic	200mg	30 + 2 Pills	83.07€ 79.11€	Buy
Viagra Generic	100mg	270 + 10 Pills	270.47€ 257.59€	Buy

Discard any unused portion after 90 days of opening the bottle.Powder for oral suspension (e.g., Revatio or generic equivalents)):Do not mix with any other medication or additional flavoring agent.Prior to reconstitution, tap the bottle to loosen the powder.Reconstitute with a total of 90 mL of water added in 2 portions.

MeSH terms

This Patient Information has been approved by the U.S. Food and Drug Administration. This product's label may have been updated. For current full prescribing information, please visit Cardura (doxazosin mesylate), and Minipress (prazosin HCl) are registered trademarks of Pfizer Inc. The other brands listed are trademarks of their respective owners and are not trademarks of Pfizer Inc. Initially, add 60 mL of water to the bottle and shake vigorously for at least 30 seconds.

Route of administration

SILDENAFIL CITRATE TABLETS may affect the way other medicines work, and other medicines may affect the way SILDENAFIL CITRATE TABLETS works causing side effects. Especially tell your healthcare provider if you take any of the following: medicines called nitrates (see "What is the most important information I should know about SILDENAFIL CITRATE TABLETS?") medicines called guanylate cyclase stimulators, such as riociguat (Adempas) medicines called alpha blockers such as Hytrin (terazosin HCl), Flomax (tamsulosin HCl), Cardura (doxazosin mesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl), Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin). Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. In some patients, the use of SILDENAFIL CITRATE TABLETS with alpha-blockers can lead to a drop in blood pressure or to fainting. medicines called HIV protease inhibitors, such as ritonavir (Norvir), indinavir sulfate (Crixivan), saquinavir (Fortovase or Invirase) or atazanavir sulfate (Reyataz) some types of oral antifungal medicines, such as ketoconazole (Nizoral), and itraconazole (Sporanox) some types of antibiotics, such as clarithromycin (Biaxin), telithromycin (Ketek), or erythromycin other medicines that treat high blood pressure SILDENAFIL CITRATE TABLETS contains sildenafil, which is the same medicine found in another drug called SILDENAFIL TABLETS.

What are the serious side effects of sildenafil?

SILDENAFIL TABLETS is used to treat a rare disease called pulmonary arterial hypertension (PAH). SILDENAFIL CITRATE TABLETS should not be used with SILDENAFIL TABLETS or with other PAH treatments containing sildenafil or any other PDE5 inhibitors (such as Adcirca [tadalafil]). Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure. How should I take SILDENAFIL CITRATE TABLETS? Take SILDENAFIL CITRATE TABLETS exactly as your healthcare provider tells you to take it.

Drugs you should not use with sildenafil

Your healthcare provider will tell you how much SILDENAFIL CITRATE TABLETS to take and when to take it. Take SILDENAFIL CITRATE TABLETS about 1 hour before sexual activity. You may take SILDENAFIL CITRATE TABLETS between 30 minutes to 4 hours before sexual activity if needed. SILDENAFIL CITRATE TABLETS can be taken with or without food. If you take SILDENAFIL CITRATE TABLETS after a high fat meal (such as a sildenafil 25mg tablets cheeseburger and french fries), SILDENAFIL CITRATE TABLETS may take a little longer to start working Do not take SILDENAFIL CITRATE TABLETS more than 1 time a day. Add the remaining 30 mL of water and shake vigorously for at least 30 seconds.Remove the cap and press the adaptor for the oral syringe into the neck of the bottle; replace cap.Write an expiration date of 60 days from the date of reconstitution on the bottle label.Storage: Store below 30 degrees C (86 degrees F) or in refrigerator at 2 to 8 degrees C (36 to 46 degrees F).

StatPearls [Internet].

If you accidentally take too much SILDENAFIL CITRATE TABLETS, call your doctor or go to the nearest hospital emergency room right away. What are the possible side effects of SILDENAFIL CITRATE TABLETS? SILDENAFIL CITRATE TABLETS can cause serious side effects. an erection that will not go away (priapism). sudden vision loss in one or both eyes.

Patient resources

It is uncertain whether PDE5 inhibitors directly cause the vision loss. Stop taking SILDENAFIL CITRATE TABLETS and call your healthcare provider right away if you have sudden vision loss in one or both eyes. If you have these symptoms, stop taking SILDENAFIL CITRATE TABLETS and contact a doctor right away. The most common side effects of SILDENAFIL CITRATE TABLETS are: abnormal vision, such as changes in color vision (such as having a blue color tinge) and blurred vision In addition, heart attack, stroke, irregular heartbeats and death have happened rarely in men taking SILDENAFIL CITRATE TABLETS. Most, but not all, of these men had heart problems before taking SILDENAFIL CITRATE TABLETS.

Postmarketing Reports

It is not known if SILDENAFIL CITRATE TABLETS caused these problems. These are not all the possible side effects of SILDENAFIL CITRATE TABLETS. For more information, ask your healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088. How should I store SILDENAFIL CITRATE TABLETS? Discard any unused portion after 60 days.

What Are Side Effects Associated with Using Sildenafil?

Store SILDENAFIL CITRATE TABLETS at room temperature between 68°F to 77°F (20°C to 25°C). Keep SILDENAFIL CITRATE TABLETS and all medicines out of the reach of children. General information about the safe and effective use of SILDENAFIL CITRATE TABLETS. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use SILDENAFIL CITRATE TABLETS for a condition for which it was not prescribed.

Generic Name

Do not give SILDENAFIL CITRATE TABLETS to other people, even if they have the same symptoms that you have. This Patient Information leaflet summarizes the most important information about SILDENAFIL CITRATE TABLETS. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about SILDENAFIL CITRATE TABLETS that is written for health professionals. For more information, go to or call 1-800-438-1985 What are the ingredients in SILDENAFIL CITRATE TABLETS? Extemporaneous 2.5 mg/mL sildenafil oral suspension:NOTE: Extemporaneously prepared sildenafil oral suspension is not approved by the FDA; an FDA-approved powder for oral suspension is now commercially available.With a mortar and pestle, grind thirty 25-mg sildenafil citrate tablets to a fine powder.In a separate container, mix 1 of the following: 1) 150 mL of Ora-Sweet with 150 mL of Ora-Plus; or 2) 150 mL of Simple Syrup, NF with 150 mL of methylcellulose 1%.Add a small amount of the mixture to the fine powder and mix into a uniform paste.

• Sildenafil citrate is a medication used primarily for erectile dysfunction.
• It works by relaxing blood vessels to increase blood flow.
• Sildenafil is also prescribed for pulmonary arterial hypertension.
• Common side effects include headache, flushing, and nasal congestion.
• It should be taken 30-60 minutes before sexual activity.
• Alcohol and high-fat meals can reduce its effectiveness.
• Do not take with nitrate medications due to risk of severe hypotension.

Add geometric amounts of the vehicle to the almost desired volume while mixing.

• Sildenafil shortens the time to achieve an erection.
• It does not cause spontaneous erections without sexual stimulation.
• Overdose signs include vision changes, persistent erections, or hypotension.
• It is linked to priapism, a sustained and painful erection.
• Always consult a healthcare provider before starting sildenafil.
• Store medication in a cool, dry place away from children.
• Combining with recreational drugs can cause dangerous interactions.

Transfer to a graduated cylinder and adjust to volume while mixing.Place in amber plastic bottles.

Site Operator

Fabienne Heyne
[email protected]

Corporate Design

Silvio Ketterer Visuelle Gestaltung
www.silvioketterer.ch

Website Programming

RHOdesign
www.rhodesign.ch

Photography

Angelika Annen
www.angelikaannen.ch